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Proceedings Paper

Porous silicon photoluminescence biosensor for rapid and sensitive detection of toxins
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Paper Abstract

A rapid and low cost photoluminescence (PL) immunosensor for the determination of low concentrations of Ochratoxin A(OTA) and Aflatoxine B1 (AfB1) has been developed. This biosensor was based on porous silicon (PSi) fabricated by metal-assisted chemical etching (MACE) and modified by antibodies against OTA/AfB1 (anti-OTA/anti-AfB1). Biofunctionalization method of the PSi surface by anti-OTA/ anti-AfB1 was developed. The changes of the PL intensity after interaction of the immobilized anti-OTA/anti-AfB1with OTA/AfB1 antigens were used as biosensor signal, allowing sensitive and selective detection of OTA/AfB1 antigens in BSA solution. The sensitivity of the reported optical biosensor towards OTA/AfB1 antigens is in the range from 10-3 to 102 ng/ml.

Paper Details

Date Published: 25 August 2017
PDF: 6 pages
Proc. SPIE 10364, Organic Sensors and Bioelectronics X, 103640V (25 August 2017); doi: 10.1117/12.2273144
Show Author Affiliations
Yulia Melnyk, Odessa I.I. Mechnikov National Univ. (Ukraine)
Karyna Pavlova, Odessa I.I. Mechnikov National Univ. (Ukraine)
Valerii Myndrul, Odessa I.I. Mechnikov National Univ. (Ukraine)
Roman Viter, Univ. of Latvia (Latvia)
Valentyn Smyntyna, Odessa I.I. Mechnikov National Univ. (Ukraine)
Igor Iatsunskyi, Adam Mickiewicz Univ. (Poland)

Published in SPIE Proceedings Vol. 10364:
Organic Sensors and Bioelectronics X
Ioannis Kymissis; Ruth Shinar; Luisa Torsi, Editor(s)

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