This paper describes a flexible model that can be used to simulate laser-based photoactivation of drug delivery systems. It considers Gaussian beams for the excitation while the heat diffusion equation is solved by use of the finite element method. As an example, a typical liposome geometry in the focal volume of a laser beam is simulated and the results are compared with experimental data obtained in the literature, showing a good agreement. The model has potential in the design of drug delivery systems as it can be a starting point for the development of new kinds of micro- and nano-scale drug delivery systems.

Date Published: 22 August 2017
PDF: 6 pages
Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 104531Y (22 August 2017); doi: 10.1117/12.2272721

Published in SPIE Proceedings Vol. 10453:
Third International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)