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Proceedings Paper

Numerical study on simultaneous emission and transmission tomography in the MRI framework
Author(s): Lars Gjesteby; Wenxiang Cong; Ge Wang
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Paper Abstract

Multi-modality imaging methods are instrumental for advanced diagnosis and therapy. Specifically, a hybrid system that combines computed tomography (CT), nuclear imaging, and magnetic resonance imaging (MRI) will be a Holy Grail of medical imaging, delivering complementary structural/morphological, functional, and molecular information for precision medicine. A novel imaging method was recently demonstrated that takes advantage of radiotracer polarization to combine MRI principles with nuclear imaging. This approach allows the concentration of a polarized Υ-ray emitting radioisotope to be imaged with MRI resolution potentially outperforming the standard nuclear imaging mode at a sensitivity significantly higher than that of MRI. In our work, we propose to acquire MRI-modulated nuclear data for simultaneous image reconstruction of both emission and transmission parameters, suggesting the potential for simultaneous CT-SPECT-MRI. The synchronized diverse datasets allow excellent spatiotemporal registration and unique insight into physiological and pathological features. Here we describe the methodology involving the system design with emphasis on the formulation for tomographic images, even when significant radiotracer signals are limited to a region of interest (ROI). Initial numerical results demonstrate the feasibility of our approach for reconstructing concentration and attenuation images through a head phantom with various radio-labeled ROIs. Additional considerations regarding the radioisotope characteristics are also discussed.

Paper Details

Date Published: 19 September 2017
PDF: 9 pages
Proc. SPIE 10391, Developments in X-Ray Tomography XI, 103910F (19 September 2017); doi: 10.1117/12.2272505
Show Author Affiliations
Lars Gjesteby, Rensselaer Polytechnic Institute (United States)
Wenxiang Cong, Rensselaer Polytechnic Institute (United States)
Ge Wang, Rensselaer Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 10391:
Developments in X-Ray Tomography XI
Bert Müller; Ge Wang, Editor(s)

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