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Proceedings Paper

Surface enhanced Raman spectroscopy analysis of HeLa cells using a multilayer substrate
Author(s): I. A. Aguilar-Hernández; J. L. Pichardo-Molina; T. Lopez-Luke; N. Ornelas-Soto
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Paper Abstract

Single cell analysis can provide important information regarding cell composition, and can be used for biomedical applications. In this work, a SERS active substrate formed by 3 layers of gold nanospheres and a final layer of gold nanocubes was used for the label-free SERS analysis of HeLa cells. Nanocubes were selected due to the high electromagnetic enhancement expected in nanoparticles with sharp corners. Significant improvement in the reproducibility and quality of SERS spectra was found when compared to the spectra obtained using a nanosphere-only substrate and normal Raman spectroscopy.

Paper Details

Date Published: 22 August 2017
PDF: 7 pages
Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 1045312 (22 August 2017); doi: 10.1117/12.2272026
Show Author Affiliations
I. A. Aguilar-Hernández, Tecnológico de Monterrey (Mexico)
J. L. Pichardo-Molina, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
T. Lopez-Luke, Ctr. de Investigaciones en Óptica, A.C. (Mexico)
N. Ornelas-Soto, Tecnológico de Monterrey (Mexico)

Published in SPIE Proceedings Vol. 10453:
Third International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)

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