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Proceedings Paper

Time-resolved SERS for characterizing extracellular vesicles
Author(s): Tatu Rojalin; Heikki Saari; Petter Somersalo; Saara Laitinen; Mikko Turunen; Tapani Viitala; Sebastian Wachsmann-Hogiu; Zachary J. Smith; Marjo Yliperttula
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Paper Abstract

The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general.

Paper Details

Date Published: 3 April 2017
PDF: 1 pages
Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 100800U (3 April 2017); doi: 10.1117/12.2271865
Show Author Affiliations
Tatu Rojalin, Univ. of Helsinki (Finland)
Heikki Saari, Univ. of Helsinki (Finland)
Petter Somersalo, Univ. of Helsinki (Finland)
Saara Laitinen, Finnish Red Cross Blood Service (Finland)
Mikko Turunen, Univ. of Eastern Finland (Finland)
Tapani Viitala, Univ. of Helsinki (Finland)
Sebastian Wachsmann-Hogiu, McGill Univ. (Canada)
Zachary J. Smith, Univ. of Science and Technology of China (China)
Marjo Yliperttula, Univ. of Helsinki (Finland)

Published in SPIE Proceedings Vol. 10080:
Plasmonics in Biology and Medicine XIV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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