A preclinical device that mimics half blood vessel by using laser technologies has been developed. By employing a Nd:YVO₄ laser a channel has been manufactured over soda-lime glass. Using a CO₂ laser combined with a roller furnace, a thermal treatment has been applied to the channel to enhance its quality. The glass structure was employed as master to replicate the channel in PDMS by soft-lithography. To avoid the deterioration of the PDMS, channels were coated with three different sol-gel coatings compositions. Endothelial cells were cultured over the channels to determine the most suitable surface for cell growing.

Date Published: 22 August 2017
PDF: 5 pages
Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 104530N (22 August 2017); doi: 10.1117/12.2271778

Published in SPIE Proceedings Vol. 10453:
Third International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)