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Proceedings Paper

Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers
Author(s): Dominika Wawrzyńczyk; Julita Kulbacka; Urszula Bazylińska
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Paper Abstract

We have investigated the change in optical properties and biocompatibility of up-converting NaYF4 nanoparticles (NPs) upon encapsulation inside the polyester nanocarriers (NCs) stabilized by Crempophor RH40 (CRH40), poly(D,L-lactide) (PLA), Pluronic P123 (P123). NaYF4:Er3+,Yb3+ NPs showed intense green and red emission, and upon encapsulation the increase of red band in respect to green one was observed, with no luminescence lifetime shortening. Obtained NCs showed prolonged colloidal stability and protective effect of the polymer shell simultaneously preserving the high emission efficiency of nanoparticles embedded within the silicon oil (SO) core. Based on emission spectra, kinetic measurements and cytotoxicity studies upon human malignant melanoma Me45 cell line we have shown the advantages of using polyester NCs as containers for the up-converting NPs. Due to the possibility of co-encapsulation of photosensitizers the obtained nanocarriers showed potential for application in theranostics.

Paper Details

Date Published: 22 August 2017
PDF: 5 pages
Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 104530K (22 August 2017); doi: 10.1117/12.2271694
Show Author Affiliations
Dominika Wawrzyńczyk, Wroclaw Univ. of Science and Technology (Poland)
Julita Kulbacka, Medical Univ. of Wroclaw (Poland)
Urszula Bazylińska, Wroclaw Univ. of Science and Technology (Poland)

Published in SPIE Proceedings Vol. 10453:
Third International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)

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