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Proceedings Paper

Study on laser-assisted drug delivery with optical coherence tomography
Author(s): Wen-Guei Tsai; Ting-Yen Tsai; Chih-Hsun Yang; Meng-Tsan Tsai
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Paper Abstract

The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. Nail plate divided into three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. Moreover, optical coherence tomography (OCT) is implemented for real-time monitoring of the laser–skin tissue interaction, sparing the patient from invasive surgical sampling procedure. Observations of drug diffusion through the induced MAZ array are achieved by evaluating the time-dependent OCT intensity variance. Subsequently, nails are treated with cream and liquid topical drugs to investigate the feasibility and diffusion efficacy of laser-assisted drug delivery. Our results show that fractional CO2 laser improves the efficacy of topical drug delivery in the nail plate, and that OCT could potentially be used for in vivo monitoring of the depth of laser penetration as well as real-time observations of drug delivery.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510T (18 April 2017); doi: 10.1117/12.2270936
Show Author Affiliations
Wen-Guei Tsai, Chang Gung Univ. (Taiwan)
Ting-Yen Tsai, Chang Gung Univ. (Taiwan)
Chih-Hsun Yang, Chang Gung Memorial Hospital (Taiwan)
Meng-Tsan Tsai, Chang Gung Univ. (Taiwan)
Chang Gung Memorial Hospital (Taiwan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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