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Proceedings Paper

Brain connectomics imaging in schizophrenia study
Author(s): Wen-Yih Isaac Tseng; Yu-Jen Chen; Yung-Chin Hsu
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Paper Abstract

Schizophrenia is a debilitating mental disorder of which the biological underpinning is still unclear. Increasing evidence in neuroscience has indicated that schizophrenia arises from abnormal connections within or between networks, hence called dysconnectvity syndrome. Recently, we established an automatic method to analyze integrity of the white matter tracts over the whole brain based on diffusion MRI data, named tract-based automatic analysis (TBAA), and used this method to study white matter connection in patients with schizophrenia. We found that alteration of tract integrity is hereditary and inherent; it is found in siblings and in patients in the early phase of disease. Moreover, patients with good treatment outcome and those with poor outcome show distinctly different patterns of alterations, suggesting that these two groups of patients might be distinguishable based on the difference in tract alteration. In summary, the altered tracts revealed by TBAA might become potential biomarkers or trait markers for schizophrenia.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025106 (18 April 2017); doi: 10.1117/12.2270425
Show Author Affiliations
Wen-Yih Isaac Tseng, National Taiwan Univ. (Taiwan)
Yu-Jen Chen, National Taiwan Univ. (Taiwan)
Yung-Chin Hsu, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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