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Proceedings Paper

Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles
Author(s): Yu-Hsuan Liu; Jia-Wei Zhang; Chih-Kuang Yeh; Kuo-Chen Wei; Hao-Li Liu; Meng-Tsan Tsai
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Paper Abstract

In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.

Paper Details

Date Published: 18 April 2017
PDF: 2 pages
Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511F (18 April 2017); doi: 10.1117/12.2269408
Show Author Affiliations
Yu-Hsuan Liu, Chang Gung Univ. (Taiwan)
Jia-Wei Zhang, Chang Gung Univ. (Taiwan)
Chih-Kuang Yeh, National Tsing Hua Univ. (Taiwan)
Kuo-Chen Wei, Chang Gung Memorial Hospital (Taiwan)
Hao-Li Liu, Chang Gung Univ. (Taiwan)
Chang Gung Memorial Hospital (Taiwan)
Meng-Tsan Tsai, Chang Gung Univ. (Taiwan)
Chang Gung Memorial Hospital (Taiwan)

Published in SPIE Proceedings Vol. 10251:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji, Editor(s)

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