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Proceedings Paper

Lung cancer diagnosis with quantitative DIC microscopy and support vector machine
Author(s): Longfei Zheng; Shuangshuang Cai; Bixin Zeng; Min Xu
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Paper Abstract

We report the study of lung squamous cell carcinoma diagnosis using the TI-DIC microscopy and the scattering-phase theorem. The spatially resolved optical properties of tissue are computed from the 2D phase map via the scattering-phase theorem. The scattering coefficient, the reduced scattering coefficient, and the anisotropy factor are all found to increase with the grade of lung cancer. The retrieved optical parameters are shown to distinguish cancer cases from the normal cases with high accuracy. This label-free microscopic approach applicable to fresh tissues may be promising for in situ rapid cancer diagnosis.

Paper Details

Date Published: 5 January 2017
PDF: 6 pages
Proc. SPIE 10245, International Conference on Innovative Optical Health Science, 102450K (5 January 2017); doi: 10.1117/12.2268806
Show Author Affiliations
Longfei Zheng, Wenzhou Medical Univ. (China)
Shuangshuang Cai, Wenzhou Medical Univ. (China)
Bixin Zeng, Wenzhou Medical Univ. (China)
Min Xu, Fairfield Univ. (United States)

Published in SPIE Proceedings Vol. 10245:
International Conference on Innovative Optical Health Science
Xingde Li; Qingming Luo, Editor(s)

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