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Proceedings Paper

Nanomedical science and laser-driven particle acceleration: promising approaches in the prethermal regime
Author(s): Y. A. Gauduel
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Paper Abstract

A major challenge of spatio-temporal radiation biomedicine concerns the understanding of biophysical events triggered by an initial energy deposition inside confined ionization tracks. This contribution deals with an interdisciplinary approach that concerns cutting-edge advances in real-time radiation events, considering the potentialities of innovating strategies based on ultrafast laser science, from femtosecond photon sources to advanced techniques of ultrafast TW laser-plasma accelerator. Recent advances of powerful TW laser sources (~1019 W cm-2) and laser-plasma interactions providing ultra-short relativistic particle beams in the energy domain 5-200 MeV open promising opportunities for the development of high energy radiation femtochemistry (HERF) in the prethermal regime of secondary low-energy electrons and for the real-time imaging of radiation-induced biomolecular alterations at the nanoscopic scale. New developments would permit to correlate early radiation events triggered by ultrashort radiation sources with a molecular approach of Relative Biological Effectiveness (RBE). These emerging research developments are crucial to understand simultaneously, at the sub-picosecond and nanometric scales, the early consequences of ultra-short-pulsed radiation on biomolecular environments or integrated biological entities. This innovating approach would be applied to biomedical relevant concepts such as the emerging domain of real-time nanodosimetry for targeted pro-drug activation and pulsed radio-chimiotherapy of cancers.

Paper Details

Date Published: 16 May 2017
PDF: 13 pages
Proc. SPIE 10239, Medical Applications of Laser-Generated Beams of Particles IV: Review of Progress and Strategies for the Future, 1023907 (16 May 2017); doi: 10.1117/12.2264974
Show Author Affiliations
Y. A. Gauduel, ENSTA ParisTech, Ecole Polytechnique, Univ. Paris-Saclay, CNRS (France)

Published in SPIE Proceedings Vol. 10239:
Medical Applications of Laser-Generated Beams of Particles IV: Review of Progress and Strategies for the Future
Kenneth W. D. Ledingham, Editor(s)

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