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Proceedings Paper

High-efficiency FRET-enhanced photoacoustic probes for in vivo tumor imaging
Author(s): Huan Qin; Liming Liu
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Paper Abstract

Photoacoustic imaging can provide high-resolution and high-contrast image under unprecedented depth compared with pure optical imaging techniques by making use of laser-induced ultrasound waves. Although a series of absorption-enhanced optical contrast agents for photoacoustic imaging were developed, the probe with fully conversion from absorbed light energy to acoustic energy has not been achieved so far. Here we develop a high-efficiency photoacoustic probes with fluorescence resonance energy transfer (FRET) effect for enhancement of nonradiative energy. Graphene oxide (GO) binding optical dyes (GO-dyes) were achieved to show highly fluorescence quenching and violently increased photoacoustic signal intensity. GO-dyes were constructed and testified for multi-spectral photoacoustic imaging. As a representative probe, GO-Cy7 nanoparticles were used to validate the feasibility of photoacoustic tumor molecular imaging in vivo. Our work demonstrated a new approach to construct high-efficiency FRET-enhanced multi-spectrum probes for photoacoustic molecular imaging.

Paper Details

Date Published: 5 January 2017
PDF: 7 pages
Proc. SPIE 10245, International Conference on Innovative Optical Health Science, 1024503 (5 January 2017); doi: 10.1117/12.2263184
Show Author Affiliations
Huan Qin, South China Normal Univ. (China)
Liming Liu, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 10245:
International Conference on Innovative Optical Health Science
Xingde Li; Qingming Luo, Editor(s)

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