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Proceedings Paper

Nano-structured optical fiber bundles for remote SPR detection: a first step toward in vivo biomolecular analysis
Author(s): Karim Vindas; Elodie Engel; Patrick Garrigue; Thierry Livache; Stéphane Arbault; Neso Sojic; Loic Leroy
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Paper Abstract

This work presents the proof of concept of the detection of global and surface optical index variations by surface plasmon resonance (SPR) thanks to optical fiber bundles. This work is the first necessary step for the future design of a lab-on-fiber tool dedicated to molecular analysis for endoscopic diagnosis. Our approach is based on nanostructured optical fiber bundles comprising several thousands of individual optical fibers. These nanostructures were coated by a thin gold layer in order to gain interesting optical properties such like SPR. The sensitivity and resolution of the bundle to global optical index changes were measured in retro-reflection. We performed numerical simulations in order to optimize the fiber tip geometry, gold coating thickness and finally enhance their analytical performances. We achieved a resolution of 10-4 refractive index unit, which is fully compatible with the detection of biological interactions involving large proteins or bacteria. Finally, we proved that our sensor was sensitive to surface optical index variations and able to detect the adsorption of a thin self-assembled molecular layer.

Paper Details

Date Published: 23 April 2017
PDF: 4 pages
Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 1032307 (23 April 2017); doi: 10.1117/12.2262559
Show Author Affiliations
Karim Vindas, Univ. Grenoble Alpes, INAC-SYMMES, CNRS (France)
CEA (France)
Elodie Engel, Univ. Grenoble Alpes, INAC-SYMMES, CNRS (France)
CEA (France)
Patrick Garrigue, Univ. Bordeaux, ISM, CNRS (France)
Thierry Livache, Univ. Grenoble Alpes, INAC-SYMMES, CNRS (France)
CEA (France)
Stéphane Arbault, Univ. Bordeaux, ISM, CNRS (France)
Neso Sojic, Univ. Bordeaux, ISM, CNRS (France)
Loic Leroy, Univ. Grenoble Alpes, INAC-SYMMES, CNRS (France)
CEA (France)

Published in SPIE Proceedings Vol. 10323:
25th International Conference on Optical Fiber Sensors
Youngjoo Chung; Wei Jin; Byoungho Lee; John Canning; Kentaro Nakamura; Libo Yuan, Editor(s)

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