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Proceedings Paper

Detection of complex molecular samples by low-cost surface enhanced raman spectroscopy (SERS) substrate
Author(s): Hsuan-Chao Hou; Yaser Mohammadi Banadaki; Safura Sharifi
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Paper Abstract

Raman scattering is a well-known technique for detecting and identifying complex molecular samples. The weak Raman signals are enormously enhanced in the presence of a nano-patterned metallic surface next to the specimen. This paper reports new techniques to obtain the nanostructures required for Surface Enhanced Raman Scattering (SERS) without costly and sophisticated fabrication steps, which are nanoimprint lithography (NIL), electrochemical deposition, electron beam induced deposition, and focus ion beam (FIB). 20 nm Au thicknesses of sputtered Au were deposited on etched household aluminum foil (base substrate) for vitro application. The Raman signal were caused by the Aluminum pre-etched times. In preliminary results, enhancement factors of 106 times were observed from SERS substrate for in vitro measurements. Moreover, the ability to perform in vivo measurements was demonstrated after removing the base aluminum foil substrate. This application allows Raman signals to be obtained from the surface or interior of opaque specimens. The nano-patterned gold may also be coupled in a probe to a remote spectrometer via an articulated arm. This opens up Raman spectroscopy for use in a clinical environment.

Paper Details

Date Published: 17 April 2017
PDF: 6 pages
Proc. SPIE 10167, Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017, 101671P (17 April 2017); doi: 10.1117/12.2258666
Show Author Affiliations
Hsuan-Chao Hou, Louisiana State Univ. (United States)
Yaser Mohammadi Banadaki, Southern Univ. (United States)
Safura Sharifi, Louisiana State Univ. (United States)

Published in SPIE Proceedings Vol. 10167:
Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017
Vijay K. Varadan, Editor(s)

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