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Proceedings Paper

A tale of two photons: radioluminescence and its application in molecular imaging
Author(s): Guillem Pratx
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Paper Abstract

Optical and ionizing radiation are two physical ways in which we can probe the living world. Until recently, these forms of radiation were used in distinct imaging and therapeutic applications—radiation therapy, photodynamic therapy, X-ray imaging, and diffuse optical tomography, to name a few. It has now been recognized that physical phenomena in which ionizing radiation and light are inherently coupled may provide powerful new capabilities for imaging and treating diseases. This presentation will review the physics and applications of radioluminescence, with a particular focus on molecular imaging. One such method, X-ray luminescence computed tomography (XLCT), uses narrow kilovolt X-ray beams to stimulate optical emissions from biologically targeted radioluminescent nanoparticles, thus providing high-resolution images even deep in tissue. A different phenomenon, Cherenkov luminescence, can also be harnessed to localize radiopharmaceuticals in vivo, allowing surgeons to visualize the molecular status of the tissues they are resecting. Recent progress towards routine implantation of these methods will be reviewed and sources of endogenous radioluminescence signal will be discussed.

Paper Details

Date Published: 8 February 2017
PDF: 9 pages
Proc. SPIE 10049, Molecular-Guided Surgery: Molecules, Devices, and Applications III, 1004916 (8 February 2017); doi: 10.1117/12.2256702
Show Author Affiliations
Guillem Pratx, Stanford Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 10049:
Molecular-Guided Surgery: Molecules, Devices, and Applications III
Brian W. Pogue; Sylvain Gioux, Editor(s)

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