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Proceedings Paper

A theranostic platform for localized magnetic fluid hyperthermia and magnetic particle imaging
Author(s): Daniel Hensley; Zhi Wei Tay; Rohan Dhavalikar; Patrick Goodwill; Bo Zheng; Carlos Rinaldi; Steven Conolly
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Paper Abstract

Magnetic fluid hyperthermia (MFH) is a promising avenue for noninvasive or minimally invasive therapies including tissue ablation, hyperthermia, and drug delivery. Magnetic particle imaging (MPI) is a promising new medical imaging modality with wide-ranging applications including angiography, cell tracking, and cancer imaging. MFH and MPI are kindred technologies leveraging the same physics: Both MFH and MPI function by exciting iron oxide magnetic nanoparticles with AC magnetic fields. In this manuscript, we show that this can be leveraged for combined MPI-MFH. The gradient fields employed in MPI can benefit MFH by providing high resolution targeting anywhere in the body, and a dual system provides opportunities for real-time diagnostic imaging feedback. Here we experimentally quantify the spatial localization of MFH using MPI gradient fields with a custom MPI-MFH system, demonstrating approximately 3 mm heating resolution in phantoms. We show an ability to precisely target phantom components as desired and provide heating of approximately 150 W g-1. We also show preliminary simultaneous MPI-MFH data.

Paper Details

Date Published: 22 February 2017
PDF: 8 pages
Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 1006603 (22 February 2017); doi: 10.1117/12.2256350
Show Author Affiliations
Daniel Hensley, Univ. of California, Berkeley (United States)
Zhi Wei Tay, Univ. of California, Berkeley (United States)
Rohan Dhavalikar, Univ. of Florida (United States)
Patrick Goodwill, Magnetic Insight, Inc. (United States)
Bo Zheng, Univ. of California, Berkeley (United States)
Carlos Rinaldi, Univ. of Florida (United States)
Steven Conolly, Univ. of California, Berkeley (United States)

Published in SPIE Proceedings Vol. 10066:
Energy-based Treatment of Tissue and Assessment IX
Thomas P. Ryan, Editor(s)

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