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Proceedings Paper

Optoacoustic mapping of cerebral blood oxygenation in humans
Author(s): Yuriy Petrov; Donald S. Prough; Irene Y. Petrov; C. Joan Richardson; Rafael A. Fonseca; Claudia S. Robertson; Rinat O. Esenaliev
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Paper Abstract

Noninvasive, transcranial mapping, monitoring, and imaging are highly important for detection and management of cerebral abnormalities and neuroscience research. Mapping, imaging, and monitoring of cerebral blood oxygenation are necessary for diagnostics and management of patients with traumatic brain injury, stroke, and other neurological conditions. We proposed to use optoacoustic technology for noninvasive, transcranial monitoring and imaging. In this work, we developed optoacoustic systems for mapping of cerebral blood oxygenation in humans and tested them in adults and neonates. The systems provide noninvasive, transcranial optoacoustic measurements in the transmission (forward) and reflection (backward) modes in the near infrared spectral range. Novel, ultra-sensitive probes were built for detection of optoacoustic signals and measurement of blood oxygenation in neonates and adults. Cerebral oxygenation was measured at different lateral sites from the superior sagittal sinus (SSS), a large central cerebral vein, located immediately beneath the midline of the human skull. In neonates, cerebral oxygenation was measured through open anterior and posterior fontanelles. Optoacoustic signal detection at different locations allowed for mapping of cerebral blood oxygenation. Our future studies will be focused on 3D mapping of cerebral blood oxygenation.

Paper Details

Date Published: 22 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640A (22 March 2017); doi: 10.1117/12.2256167
Show Author Affiliations
Yuriy Petrov, The Univ. of Texas Medical Branch (United States)
Donald S. Prough, The Univ. of Texas Medical Branch (United States)
Irene Y. Petrov, The Univ. of Texas Medical Branch (United States)
C. Joan Richardson, The Univ. of Texas Medical Branch (United States)
Rafael A. Fonseca, The Univ. of Texas Medical Branch (United States)
Claudia S. Robertson, Baylor College of Medicine (United States)
Rinat O. Esenaliev, The Univ. of Texas Medical Branch (United States)


Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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