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Proceedings Paper

Enhanced scatter contrast color imaging of tissue: methods for comparing high spatial frequency domain and cross-polarization scatter images
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Paper Abstract

This paper describes the system calibration and demodulation procedures used in an investigation of the scatter-specific tissue contrast that can be obtained by high spatial frequency (HSF) domain imaging and cross- polarization (CP) imaging using an inexpensive color imaging system.

HSF and CP imaging methods are both known to alter the reflectance image sensitivity to diffuse multiply- scattered and superficially backscattered photons. This results in enhanced contrast, compared to standard wide-field imaging, based on tissue surface microstructure and composition. Measurements in tissue-simulating optical phantoms show that CP images display contrast based on both scattering and absorption, while HSF is specifically sensitive to scatter-only contrast, strongly suppressing absorption-based contrast. By altering the frequency used, the degree of contrast suppression or enhancement can be tuned.1 This suggests that an inexpensive HSF imaging system could have potential to aid diagnostic procedures, where CP is the current state-of-the-art imaging modality.

Paper Details

Date Published: 17 February 2017
PDF: 9 pages
Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100590B (17 February 2017); doi: 10.1117/12.2256027
Show Author Affiliations
Mackenzie L. Carlson, Dartmouth College (United States)
David M. McClatchy III, Dartmouth College (United States)
Jason R. Gunn, Dartmouth College (United States)
Jonathan T. Elliott, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)
Norris Cotton Cancer Ctr., Dartmouth Hitchcock Medical Ctr. (United States)
Stephen C. Kanick, Dartmouth College (United States)
Profusa, Inc. (United States)
Brian W. Pogue, Dartmouth College (United States)
Norris Cotton Cancer Ctr., Dartmouth Hitchcock Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 10059:
Optical Tomography and Spectroscopy of Tissue XII
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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