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Proceedings Paper • Open Access

The effect of hypofractionated radiation and magnetic nanoparticle hyperthermia on tumor immunogenicity and overall treatment response
Author(s): P. Jack Hoopes D.V.M.; Robert J. Wagner; Ailin Song; Bjorn Osterberg; David J. Gladstone; Alicea A. Bursey; Steven N. Fiering; Andrew J. Giustini M.D.

Paper Abstract

It is now known that many tumors develop molecular signals (immune checkpoint modulators) that inhibit an effective tumor immune response. New information also suggest that even well-known cancer treatment modalities such as radiation and hyperthermia generate potentially beneficial immune responses that have been blocked or mitigated by such immune checkpoints, or similar molecules. The cancer therapy challenge is to; a) identify these treatment-based immune signals (proteins, antigens, etc.); b) the treatment doses or regimens that produce them; and c) the mechanisms that block or have the potential to promote them. The goal of this preliminary study, using the B6 mouse – B16 tumor model, clinically relevant radiation doses and fractionation schemes (including those used clinically in hypofractionated radiation therapy), magnetic nanoparticle hyperthermia (mNPH) and sophisticated protein, immune and tumor growth analysis techniques and modulators, is to determine the effect of specific radiation or hyperthermia alone and combined on overall treatment efficacy and immunologic response mechanisms. Preliminary analysis suggests that radiation dose (10 Gy vs. 2 Gy) significantly alters the mechanism of cell death (apoptosis vs. mitosis vs. necrosis) and the resulting immunogenicity. Our hypothesis and data suggest this difference is protein/antigen and immune recognition-based. Similarly, our evidence suggest that radiation doses larger than the conventional 2 Gy dose and specific hyperthermia doses and techniques (including mNP hyperthermia treatment) can be immunologically different, and potentially superior to, the radiation and heat therapy regimens that are typically used in research and clinical practice.

Paper Details

Date Published: 23 February 2017
PDF: 6 pages
Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 100660D (23 February 2017); doi: 10.1117/12.2255981
Show Author Affiliations
P. Jack Hoopes D.V.M., Geisel School of Medicine at Dartmouth (United States)
Robert J. Wagner, Geisel School of Medicine at Dartmouth (United States)
Ailin Song, Geisel School of Medicine at Dartmouth (United States)
Bjorn Osterberg, Geisel School of Medicine at Dartmouth (United States)
David J. Gladstone, Geisel School of Medicine at Dartmouth (United States)
Alicea A. Bursey, Geisel School of Medicine at Dartmouth (United States)
Steven N. Fiering, Geisel School of Medicine at Dartmouth (United States)
Andrew J. Giustini M.D., Stanford Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 10066:
Energy-based Treatment of Tissue and Assessment IX
Thomas P. Ryan, Editor(s)

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