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Proceedings Paper

Raman spectroscopic characterization of urine of normal and cervical cancer subjects
Author(s): Raja Pappu; Aruna Prakasarao; Koteeswaran Dornadula; Ganesan Singaravelu
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Paper Abstract

Cervical cancer is the fourth most common malignancy in female worldwide; the present method for diagnosis is the biopsy, Pap smear, colposcopy etc. To overcome the drawbacks of diagnosis an alternative technique is required, optical spectroscopy is a new technique where the discrimination of normal and cancer subjects provides valuable potential information in the diagnostic oncology at an early stage. Raman peaks in the spectra suggest interesting differences in various bio molecules. In this regard, non invasive optical detection of cervical cancer using urine samples by Raman Spectroscopy combined with LDA diagnostic algorithm yields an accuracy of 100% for original and cross validated group respectively. As the results were appreciable it is necessary to carry out the analysis for more number of samples to explore the facts hidden at different stages during the development of cervical cancer.

Paper Details

Date Published: 14 February 2017
PDF: 7 pages
Proc. SPIE 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, 1005404 (14 February 2017); doi: 10.1117/12.2255878
Show Author Affiliations
Raja Pappu, Anna Univ., Chennai (India)
Aruna Prakasarao, Anna Univ., Chennai (India)
Koteeswaran Dornadula, Meenakshi Ammal Dental College & Hospital (India)
Ganesan Singaravelu, Anna Univ., Chennai (India)

Published in SPIE Proceedings Vol. 10054:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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