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Proceedings Paper

Blood-pool contrast agent for pre-clinical computed tomography
Author(s): Charmainne Cruje; Justin J. Tse; David W. Holdsworth; Elizabeth R. Gillies; Maria Drangova
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Paper Abstract

Advances in nanotechnology have led to the development of blood-pool contrast agents for micro-computed tomography (micro-CT). Although long-circulating nanoparticle-based agents exist for micro-CT, they are predominantly based on iodine, which has a low atomic number. Micro-CT contrast increases when using elements with higher atomic numbers (i.e. lanthanides), particularly at higher energies. The purpose of our work was to develop and evaluate a lanthanide-based blood-pool contrast agent that is suitable for in vivo micro-CT. We synthesized a contrast agent in the form of polymer-encapsulated Gd nanoparticles and evaluated its stability in vitro. The synthesized nanoparticles were shown to have an average diameter of 127 ± 6 nm, with good size dispersity. Particle size distribution -- evaluated by dynamic light scattering over the period of two days -- demonstrated no change in size of the contrast agent in water and saline. Additionally, our contrast agent was stable in a mouse serum mimic for up to 30 minutes. CT images of the synthesized contrast agent (containing 27 mg/mL of Gd) demonstrated an attenuation of over 1000 Hounsfield Units. This approach to synthesizing a Gd-based blood-pool contrast agent promises to enhance the capabilities of micro-CT imaging.

Paper Details

Date Published: 9 March 2017
PDF: 6 pages
Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101321M (9 March 2017); doi: 10.1117/12.2255581
Show Author Affiliations
Charmainne Cruje, Robarts Research Institute, Western Univ. (Canada)
Western Univ. (Canada)
Justin J. Tse, Robarts Research Institute, Western Univ. (Canada)
Western Univ. (Canada)
David W. Holdsworth, Robarts Research Institute, Western Univ. (Canada)
Western Univ. (Canada)
Elizabeth R. Gillies, Western Univ. (Canada)
Maria Drangova, Robarts Research Institute, Western Univ. (Canada)
Western Univ. (Canada)

Published in SPIE Proceedings Vol. 10132:
Medical Imaging 2017: Physics of Medical Imaging
Thomas G. Flohr; Joseph Y. Lo; Taly Gilat Schmidt, Editor(s)

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