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Proceedings Paper

Hypericin-mediated selective photomodification of connective tissues
Author(s): V. Hovhannisyan; A. Hovhannisyan; V. Ghukasyan; H. W. Guo; Hung-Ming Lin; S. J. Chen; Yang-Fang Chen; Chen-Yuan Dong
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Paper Abstract

Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues. Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp–mediated processes in collagen tissues may be used for the selective modification of collagen fibers.

Paper Details

Date Published: 13 February 2017
PDF: 6 pages
Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 100370O (13 February 2017); doi: 10.1117/12.2255028
Show Author Affiliations
V. Hovhannisyan, National Chiao Tung Univ. (Taiwan)
A. Hovhannisyan, European Regional Education Academy (Armenia)
V. Ghukasyan, The Univ. of North Carolina at Chapel Hill (United States)
H. W. Guo, National Taiwan Univ. (Taiwan)
Hung-Ming Lin, National Taiwan Univ. (Taiwan)
S. J. Chen, National Chiao Tung Univ. (Taiwan)
Yang-Fang Chen, National Taiwan Univ. (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 10037:
Photonics in Dermatology and Plastic Surgery
Bernard Choi; Haishan Zeng; Nikiforos Kollias, Editor(s)

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