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Proceedings Paper

Direct visualization of functional heterogeneity in hepatobiliary metabolism
Author(s): Chih-Ju Lin; Feng-Chieh Li; Yu-Yang Lee; Te-Yu Tseng; Wei-Lian Chen; Vladimir Hovhannisyan; Ning Kang; Nicholas G. Horton; Shu-Jen Chiang; Chris Xu; Hsuan-Shu Lee M.D.; Chen-Yuan Dong
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Paper Abstract

Hepatycotes in the liver may appear similar in morphology, however, heterogeneities may exist in cellular metabolism. In this study, in vivo imaging of 6-carboxfluorescein diacetate (6-CFDA) metabolism in the liver was studied. We used two-photon fluorescence microscopy and hepatic window to provide quantification in studying hepatocellular metabolism. This model not only provides a potential platform for future study in hepatic responses and regulations, but also contributes to the fine-tuning of organ-specific functions so as to open up a new era of exciting discoveries.

Paper Details

Date Published: 13 February 2017
PDF: 8 pages
Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 100460C (13 February 2017); doi: 10.1117/12.2254952
Show Author Affiliations
Chih-Ju Lin, National Taiwan Univ. (Taiwan)
Feng-Chieh Li, National Taiwan Univ. (Taiwan)
Yu-Yang Lee, National Taiwan Univ. (Taiwan)
Te-Yu Tseng, National Taiwan Univ. (Taiwan)
Wei-Lian Chen, National Taiwan Univ. (Taiwan)
Vladimir Hovhannisyan, National Taiwan Univ. (Taiwan)
Ning Kang, National Taiwan Univ. (Taiwan)
Nicholas G. Horton, Cornell Univ. (United States)
Shu-Jen Chiang, National Taiwan Univ. (Taiwan)
Chris Xu, Cornell Univ. (United States)
Hsuan-Shu Lee M.D., National Taiwan Univ. Hospital (Taiwan)
National Taiwan Univ. (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 10046:
Visualizing and Quantifying Drug Distribution in Tissue
Kin Foong Chan; Conor L. Evans, Editor(s)

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