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Proceedings Paper

Birefringence phantoms for polarization sensitive optical coherence tomography (Conference Presentation)
Author(s): Xinyu Liu Sr.; Martin Villiger; Kathy Beaudette; Linbo Liu; Brett E. Bouma

Paper Abstract

Polarization sensitive optical coherence tomography (PS-OCT) is increasingly used in a range of applications, both in bench-top and catheter-based imaging configurations. Reconstruction of tissue birefringence is subject to many system and processing-dependent artifacts. However, methods for the calibration and validation of PS-OCT are missing. Here, we report on a method to fabricate tissue-like imaging phantoms exhibiting clearly defined regions with controllable amounts of birefringence. We employed the photoelastic effect to enable the generation of controllable amounts of stress-induced birefringence in rubber samples, verified with polarized light microscopy. Pigmented ink was added to liquid latex solution to mold and cure rubber bands with controlled backscattering and transparency. Differently stretched segments were embedded in a stress-free background matrix to generate clearly defined areas with high birefringence contrast in an area of homogenous backscatter intensity. Arranged in planar geometry or on the outside of a glass capillary, the stretched rubber bands defined phantoms for bench-top and catheter-based imaging, respectively. Segmentation of the defined regions of interest in the reconstructed volumetric birefringence tomograms enabled assessing measurement consistency, between repeated imaging with a single system, or between independent imaging systems. Consistent and durable imaging phantoms are crucial for advancing PS-OCT imaging technology. Our tissue-like imaging phantoms exhibit clearly defined regions with controlled amounts of birefringence and facilitate testing, calibration, and validation of imaging systems and reconstruction strategies.

Paper Details

Date Published: 19 April 2017
PDF: 1 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100531C (19 April 2017); doi: 10.1117/12.2254896
Show Author Affiliations
Xinyu Liu Sr., Nanyang Technological Univ. (Singapore)
Martin Villiger, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Kathy Beaudette, Ecole Polytechnique de Montréal (Canada)
Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Linbo Liu, Nanyang Technological Univ. (Singapore)
Brett E. Bouma, Massachusetts General Hospital (United States)
Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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