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Proceedings Paper

Functional photoacoustic tomography for neonatal brain imaging: developments and challenges
Author(s): Ali Hariri; Emytis Tavakoli; Saba Adabi; Juri Gelovani; Mohammad R. N. Avanaki
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Paper Abstract

Transfontanelle ultrasound imaging (TFUSI) is a routine diagnostic brain imaging method in infants who are born prematurely, whose skull bones have not completely fused together and have openings between them, so-called fontanelles. Open fontanelles in neonates provide acoustic windows, allowing the ultrasound beam to freely pass through. TFUSI is used to rule out neurological complications of premature birth including subarachnoid hemorrhage (SAH), intraventricular (IVH), subependimal (SEPH), subdural (SDH) or intracerebral (ICH) hemorrhages, as well as hypoxic brain injuries. TFUSI is widely used in the clinic owing to its low cost, safety, accessibility, and noninvasive nature. Nevertheless, the accuracy of TFUSI is limited. To address several limitations of current clinical imaging modalities, we develop a novel transfontanelle photoacoustic imaging (TFPAI) probe, which, for the first time, should allow for non-invasive structural and functional imaging of the infant brain. In this study, we test the feasibility of TFPAI for detection of experimentally-induced intra ventricular and Intraparenchymal hemorrhage phantoms in a sheep model with a surgically-induced cranial window which will serve as a model of neonatal fontanelle. This study is towards using the probe we develop for bedside monitoring of neonates with various disease conditions and complications affecting brain perfusion and oxygenation, including apnea, asphyxia, as well as for detection of various types of intracranial hemorrhages (SAH, IVH, SEPH, SDH, ICH).

Paper Details

Date Published: 3 March 2017
PDF: 8 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642Z (3 March 2017); doi: 10.1117/12.2254861
Show Author Affiliations
Ali Hariri, Wayne State Univ. (United States)
Emytis Tavakoli, Wayne State Univ. School of Medicine (United States)
Tehran Psychiatric Institute (Iran, Islamic Republic of)
Saba Adabi, Wayne State Univ. (United States)
Juri Gelovani, Wayne State Univ. (United States)
Barbara Ann Karmanos Cancer Institute (United States)
Mohammad R. N. Avanaki, Wayne State Univ. (United States)
Barbara Ann Karmanos Cancer Institute (United States)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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