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Proceedings Paper

Quantification of oxygen changes in the placenta from BOLD MR image sequences
Author(s): Antonio R. Porras; Gemma Piella; Wonsang You; Catherine Limperopoulos; Marius George Linguraru
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Paper Abstract

Functional analysis of the placenta is important to analyze and understand its role in fetal growth and development. BOLD MR is a non-invasive technique that has been extensively used for functional analysis of the brain. During the last years, several studies have shown that this dynamic image modality is also useful to extract functional information of the placenta. We propose in this paper a method to track the placenta from a sequence of BOLD MR images acquired under normoxia and hyperoxia conditions with the goal of quantifying how the placenta adapts to oxygenation changes. The method is based on a spatiotemporal transformation model that ensures temporal coherence of the tracked structures. The method was initially applied to four patients with healthy pregnancies. An average MR signal increase of 16.96±8.39% during hyperoxia was observed. These automated results are in line with state-of-the-art reports using time-consuming manual segmentations subject to inter-observer errors.

Paper Details

Date Published: 3 March 2017
PDF: 6 pages
Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 1013406 (3 March 2017); doi: 10.1117/12.2254352
Show Author Affiliations
Antonio R. Porras, Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System (United States)
Gemma Piella, Univ. Pompeu Fabra (Spain)
Wonsang You, Children's National Health System (United States)
Catherine Limperopoulos, Children's National Health System (United States)
Marius George Linguraru, Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System (United States)
School of Medicine and Health Sciences, George Washington Univ. (United States)

Published in SPIE Proceedings Vol. 10134:
Medical Imaging 2017: Computer-Aided Diagnosis
Samuel G. Armato III; Nicholas A. Petrick, Editor(s)

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