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Proceedings Paper

Computer simulation of low-dose CT with clinical lung image database: a preliminary study
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Paper Abstract

Large samples of raw low-dose CT (LDCT) projections on lungs are needed for evaluating or designing novel and effective reconstruction algorithms suitable for lung LDCT imaging. However, there exists radiation risk when getting them from clinical CT scanning. To avoid the problem, a new strategy for producing large samples of lung LDCT projections with computer simulations is proposed in this paper. In the simulation, clinical images from the publicly available medical image database-the Lung Image Database Consortium(LIDC) and Image Database Resource Initiative (IDRI) database (LIDC/IDRI) are used as the projected object to form the noise-free sinogram. Then by adding a Poisson distributed quantum noise plus Gaussian distributed electronic noise to the projected transmission data calculated from the noise-free sinogram, different noise levels of LDCT projections are obtained. At last the LDCT projections are used for evaluating two reconstruction strategies. One is the conventional filtered back projection (FBP) algorithm and the other is FBP reconstruction from the filtered sinogram with penalized weighted least square criterion (PWLS-FBP). Images reconstructed with the LDCT simulations have shown that the PWLS-FBP algorithm performs better than the FBP algorithm in reducing streaking artifacts and preserving resolution. Preliminary results indicate that the feasibility of the proposed lung LDCT simulation strategy for helping to determine advanced reconstruction algorithms.

Paper Details

Date Published: 9 March 2017
PDF: 6 pages
Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101322U (9 March 2017); doi: 10.1117/12.2253973
Show Author Affiliations
Junyan Rong, Fourth Military Medical Univ. (China)
Peng Gao, Fourth Military Medical Univ. (China)
Wenlei Liu, Fourth Military Medical Univ. (China)
Yuanke Zhang, Fourth Military Medical Univ. (China)
Tianshuai Liu, Fourth Military Medical Univ. (China)
Hongbing Lu, Fourth Military Medical Univ. (China)

Published in SPIE Proceedings Vol. 10132:
Medical Imaging 2017: Physics of Medical Imaging
Thomas G. Flohr; Joseph Y. Lo; Taly Gilat Schmidt, Editor(s)

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