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Proceedings Paper

In vivo photoacoustic imaging of uterine cervical lesion and its image processing based on light propagation in biological medium
Author(s): Shinpei Okawa; Kiguna Sei M.D.; Takeshi Hirasawa; Kaku Irisawa; Kazuhiro Hirota; Takatsugu Wada; Toshihiro Kushibiki; Kenichi Furuya M.D.; Miya Ishihara
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Paper Abstract

For diagnosis of cervical cancer, screening by colposcope and successive biopsy are usually carried out. Colposcope, which is a mesoscope, is used to examine surface of the cervix and to find precancerous lesion grossly. However, the accuracy of colposcopy depends on the skills of the examiner and is inconsistent as a result. Additionally, colposcope lacks depth information. It is known that microvessel density and blood flow in cervical lesion increases associated with angiogenesis. Therefore, photoacoustic imaging (PAI) to detect angiogenesis in cervical lesion has been studied. PAI can diagnose cervical lesion sensitively and provide depth information. The authors have been investigating the efficacy of PAI in the diagnoses of the cervical lesion and cancer by use of the PAI and ultrasonography system with transvaginal probe developed by Fujifilm Corporation. For quantitative diagnosis by use of PAI, it is required to take the light propagation in biological medium into account. The image reconstruction of the absorption coefficient from the PA image of cervix by use of the simulation of light propagation based on finite element method has been tried in this study. Numerical simulation, phantom experiment and in vivo imaging were carried out.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642S (3 March 2017); doi: 10.1117/12.2253716
Show Author Affiliations
Shinpei Okawa, National Defense Medical College (Japan)
Kiguna Sei M.D., National Defense Medical College (Japan)
Takeshi Hirasawa, National Defense Medical College (Japan)
Kaku Irisawa, FUJIFILM Corp. (Japan)
Kazuhiro Hirota, FUJIFILM Corp. (Japan)
Takatsugu Wada, FUJIFILM Corp. (Japan)
Toshihiro Kushibiki, National Defense Medical College (Japan)
Kenichi Furuya M.D., National Defense Medical College (Japan)
Miya Ishihara, National Defense Medical College (Japan)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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