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Proceedings Paper

Changes in optical properties during heating of ex vivo liver tissues
Author(s): Vivek Krishna Nagarajan; Venkateshwara R. Gogineni; Sarah B. White M.D.; Bing Yu
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Paper Abstract

Thermal ablation is the use of heat to induce cell death through coagulative necrosis. Ideally, complete ablation of tumor cells with no damage to surrounding critical structures such as blood vessels, nerves or even organs is desired. Ablation monitoring techniques are often employed to ensure optimal tumor ablation. In thermal tissue ablation, tissue damage is known to be dependent on the temperature and time of exposure. Aptly, current methods for monitoring ablation rely profoundly on local tissue temperature and duration of heating to predict the degree of tissue damage. However, such methods do not take into account the microstructural and physiological changes in tissues as a result of thermocoagulation. Light propagation within biological tissues is known to be dependent on the tissue microstructure and physiology. During tissue denaturation, changes in tissue structure alter light propagations in tissue which could be used to directly assess the extent of thermal tissue damage. We report the use of a spectroscopic system for monitoring the tissue optical properties during heating of ex vivo liver tissues. We observed that during tissue denaturation, continuous changes in wavelength-averaged μa(λ) and μ’s(λ) followed a sigmoidal trend and are correlated with damage predicted by Arrhenius model.

Paper Details

Date Published: 22 February 2017
PDF: 7 pages
Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 100660O (22 February 2017); doi: 10.1117/12.2253479
Show Author Affiliations
Vivek Krishna Nagarajan, The Univ. of Akron (United States)
Venkateshwara R. Gogineni, Medical College of Wisconsin (United States)
Sarah B. White M.D., Medical College of Wisconsin (United States)
Bing Yu, Marquette Univ. (United States)

Published in SPIE Proceedings Vol. 10066:
Energy-based Treatment of Tissue and Assessment IX
Thomas P. Ryan, Editor(s)

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