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Proceedings Paper

Nanoscale patterning of biopolymers for controlled microfluidic behavior and drug release (Conference Presentation)
Author(s): Akshit Peer; Rabin Dhakal; Rana Biswas; Jaeyoun Kim

Paper Abstract

It is of great interest to pattern biomaterials on the nanoscale and microscale to control diverse biomedical functions. We utilize soft lithographic technique to nanopattern poly (L-lactic acid) (PLLA) - a biodegradable and biocompatible polymer. We find that the PLLA surfaces nanopatterned with 750 nm pitch nanocup or nanocone arrays exhibit drug release rates 25-30% lower than that of the flat surface, which is counter-intuitive given the nanopattern-induced increase in their surface areas. Based on diffusion and microfluidic meniscus curvature minimization analyses, we attribute the decreased drug release rate to the incomplete wetting of the nanopatterned surface by the fluid.

Paper Details

Date Published: 24 April 2017
PDF: 1 pages
Proc. SPIE 10061, Microfluidics, BioMEMS, and Medical Microsystems XV, 100610B (24 April 2017); doi: 10.1117/12.2253246
Show Author Affiliations
Akshit Peer, Iowa State Univ. (United States)
Ames Lab. (United States)
Rabin Dhakal, Iowa State Univ. (United States)
Rana Biswas, Iowa State Univ. (United States)
Ames Lab. (United States)
Jaeyoun Kim, Iowa State Univ. (United States)

Published in SPIE Proceedings Vol. 10061:
Microfluidics, BioMEMS, and Medical Microsystems XV
Bonnie L. Gray; Holger Becker, Editor(s)

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