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Proceedings Paper

Single-molecule DNA hybridization on nanoporous gold nanoparticle array chip
Author(s): Jingting Li; Fusheng Zhao; Wei-Chuan Shih
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Paper Abstract

DNA hybridization, where two single-stranded DNA molecules form duplex through sequence-specific interactions, is a fundamental biological process. To gain better understanding, sequence-specific detection of hybridization at the singlemolecule level has been instrumental and can find a wide variety of applications. Nanoporous gold nanoparticle (NPGNP) array chip features large specific surface area and high-density plasmonic field enhancement known as “hot-spots” that are attractive in nanoplasmonic sensor development. In this paper, we discuss results on detecting single-molecule DNA hybridization on functionalizing NPG-NP array chip with unique bio-recognition elements towards both high sensitivity and specificity.

Paper Details

Date Published: 22 February 2017
PDF: 5 pages
Proc. SPIE 10075, Biophysics, Biology and Biophotonics II: the Crossroads, 1007505 (22 February 2017); doi: 10.1117/12.2253128
Show Author Affiliations
Jingting Li, Univ. of Houston (United States)
Fusheng Zhao, Univ. of Houston (United States)
Wei-Chuan Shih, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 10075:
Biophysics, Biology and Biophotonics II: the Crossroads
Adam Wax; Vadim Backman, Editor(s)

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