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Proceedings Paper

Comparative study of the optical properties of colon mucosa and colon precancerous polyps between 400 and 1000 nm
Author(s): Sónia Carvalho; Nuno Gueiral; Elisabete Nogueira; Rui Henrique; Luís Oliveira; Valery V. Tuchin
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Paper Abstract

Optical properties of biological tissues are unique and may be used for tissue identification, tissue discrimination or even to identify pathologies. Early stage colorectal cancer evolves from adenomatous polyps that arise in the inner layer of the colorectal tube — the mucosa. The identification of different optical properties between healthy and pathological colorectal tissues might be used to identify different tissue components and to develop an early stage diagnosis method using optical technologies. Since most of the biomedical optics techniques use light within the visible and near infrared wavelength ranges, we used the inverse adding-doubling method to make a fast estimation of the optical properties of colorectal mucosa and early stage adenocarcinoma between 400 and 1000 nm. The estimated wavelength dependencies have provided information about higher lipid content in healthy mucosa and higher blood content in pathological tissue. Such data has also indicated that the wavelength dependence of the scattering coefficient for healthy mucosa is dominated by Rayleigh scattering and for pathological mucosa it is dominated by Mie scattering. Such difference indicates smaller scatterer size in healthy mucosa tissue. Such information can now be used to develop new diagnosis or treatment methods for early cancer detection or removal. One possibility is to use optical clearing technique to improve tissue transparency and create localized and temporary tissue dehydration for image contrast improvement during diagnosis or polyp laser removal. Such techniques can now be developed based on the different results that we have found for healthy and pathological colorectal mucosa.

Paper Details

Date Published: 3 March 2017
PDF: 16 pages
Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100631L (3 March 2017); doi: 10.1117/12.2253023
Show Author Affiliations
Sónia Carvalho, Portuguese Oncology Institute of Porto (Portugal)
Nuno Gueiral, Polytechnic of Porto (Portugal)
ISEP (Portugal)
Elisabete Nogueira, Polytechnic of Porto (Portugal)
ISEP (Portugal)
Rui Henrique, Portuguese Oncology Institute of Porto (Portugal)
Institute of Biomedical Sciences Abel Salazar, Univ. of Porto (Portugal)
Luís Oliveira, Portuguese Oncology Institute of Porto (Portugal)
ISEP (Portugal)
Valery V. Tuchin, Saratov National Research State Univ. (Russian Federation)
Precision Mechanics and Control Institute (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 10063:
Dynamics and Fluctuations in Biomedical Photonics XIV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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