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Proceedings Paper

Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules
Author(s): Georgi I. Petrov; Vladislav V. Yakovlev
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Paper Abstract

Many biologically active molecules are chiral. Many drugs, which are currently in use, are supplied as an equimolar mixture of enantiomers. Although they have the same chemical structure, i.e. are not distinguishable by conventional Raman spectroscopy, most isomers of chiral drugs exhibit marked differences in biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism, etc. In this report we introduced a new spectroscopic tool to extend nonlinear Raman spectroscopy to chiral substances.

Paper Details

Date Published: 21 February 2017
PDF: 4 pages
Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 1004604 (21 February 2017); doi: 10.1117/12.2252944
Show Author Affiliations
Georgi I. Petrov, Texas A&M Univ. (United States)
Vladislav V. Yakovlev, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 10046:
Visualizing and Quantifying Drug Distribution in Tissue
Kin Foong Chan; Conor L. Evans, Editor(s)

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