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Proceedings Paper

Flexible inorganic light emitting diodes and transparent PEDOT:PSS/Parylene C for simultaneous optogenetics and electrocorticography (Conference Presentation)
Author(s): Keundong Lee; Mehran Ganji; Lorraine Hossain; Yun Goo Ro; Sang Heon Lee; Jong-woo Park; Dongha Yoo; Jiyoung Yoon; Gyu-Chul Yi; Shadi A. Dayeh

Paper Abstract

Electrocorticography (ECoG) is a powerful tool for direct mapping of local field potentials from the brain surface. Progress in development of high-fidelity materials such as poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) on thin conformal substrates such as parylene C enabled intimate contact with cortical surfaces and higher quality recordings from small volumes of neurons. Meanwhile, stimulation of neuronal activity is conventionally accomplished with electrical microstimulation and transcranial magnetic stimulation that can be combined with ECoG to form the basis of bidirectional neural interface. However, these stimulation mechanisms are less controlled and primitively understood on the local and cellular levels. With the advent of optogenetics, the localization and specificity of neuronal stimulation and inhibition is possible. Therefore, the development of integrated devices that can merge the sensitivity of ECoG or depth recording with optogenetic tools can lead to newer frontiers in understanding the neuronal activity. Herein, we introduce a hybrid device comprising flexible inorganic LED arrays integrated PEDOT:PSS/parylene C microelectrode arrays for high resolution bidirectional neuronal interfaces. The flexible inorganic LEDs have been developed by the metal-organic vapor phase epitaxy of position-controlled GaN microLEDs on ZnO nanostructured templates pre-grown at precise locations on a graphene layer. By transferring it onto the microelectrode arrays, it can provides the individual electrical addressability by light stimulation patterns. We will present experimental and simulation results on the optoelectronic characteristics and light activation capability of flexible microLEDs and their evaluation in vivo.

Paper Details

Date Published: 19 April 2017
PDF: 1 pages
Proc. SPIE 10052, Optogenetics and Optical Manipulation, 1005208 (19 April 2017); doi: 10.1117/12.2252926
Show Author Affiliations
Keundong Lee, Seoul National Univ. (Korea, Republic of)
Mehran Ganji, Univ. of California, San Diego (United States)
Lorraine Hossain, Univ. of California, San Diego (United States)
Yun Goo Ro, Univ. of California, San Diego (United States)
Sang Heon Lee, Univ. of California, San Diego (United States)
Jong-woo Park, Seoul National Univ. (Korea, Republic of)
Dongha Yoo, Seoul National Univ. (Korea, Republic of)
Jiyoung Yoon, Seoul National Univ. (Korea, Republic of)
Gyu-Chul Yi, Seoul National Univ. (Korea, Republic of)
Shadi A. Dayeh, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 10052:
Optogenetics and Optical Manipulation
Samarendra K. Mohanty; Nitish V. Thakor; E. Duco Jansen, Editor(s)

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