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Proceedings Paper

Direct numerical simulation of microcavitation processes in different bio environments
Author(s): Kevin Ly; Sy-Bor Wen; Morgan S. Schmidt; Robert J. Thomas
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Paper Abstract

Laser-induced microcavitation refers to the rapid formation and expansion of a vapor bubble inside the bio-tissue when it is exposed to intense, pulsed laser energy. With the associated microscale dissection occurring within the tissue, laserinduced microcavitation is a common approach for high precision bio-surgeries. For example, laser-induced microcavitation is used for laser in-situ keratomileusis (LASIK) to precisely reshape the midstromal corneal tissue through excimer laser beam.

Multiple efforts over the last several years have observed unique characteristics of microcavitions in biotissues. For example, it was found that the threshold energy for microcavitation can be significantly reduced when the size of the biostructure is increased. Also, it was found that the dynamics of microcavitation are significantly affected by the elastic modules of the bio-tissue. However, these efforts have not focused on the early events during microcavitation development.

In this study, a direct numerical simulation of the microcavitation process based on equation of state of the biotissue was established. With the direct numerical simulation, we were able to reproduce the dynamics of microcavitation in water-rich bio tissues. Additionally, an experimental setup in deionized water and 10% PAA gel was made to verify the results of the simulation for early micro-cavitation formation for 10% Polyacrylamide (PAA) gel in deionized water.

Paper Details

Date Published: 15 February 2017
PDF: 13 pages
Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII, 1006209 (15 February 2017); doi: 10.1117/12.2252804
Show Author Affiliations
Kevin Ly, Texas A&M Univ. (United States)
Sy-Bor Wen, Texas A&M Univ. (United States)
Morgan S. Schmidt, Air Force Research Lab. (United States)
Robert J. Thomas, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 10062:
Optical Interactions with Tissue and Cells XXVIII
E. Duco Jansen; Hope Thomas Beier, Editor(s)

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