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Proceedings Paper

Optimal selection of laser modulation parameters in photothermal optical coherence tomography
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Paper Abstract

Photothermal optical coherence tomography (PT-OCT) employs a secondary intensity-modulated photothermal laser to create modulated thermal strains that cause variations of the refractive index in the proximity of absorbing chromophores. These variations are directly detected with phase-sensitive OCT and offer insight to the molecular composition and thermo-elastic properties of the sample. Here, we define optimal PT laser modulation parameters by investigating the effect of PT laser power and modulation frequency on the ensuing thermal waves and thermal waves’ impact on the spatial resolution of PT-OCT imaging based on numerical simulations of PT-OCT and samples containing point absorbers.

Paper Details

Date Published: 21 February 2017
PDF: 9 pages
Proc. SPIE 10067, Optical Elastography and Tissue Biomechanics IV, 1006718 (21 February 2017); doi: 10.1117/12.2252779
Show Author Affiliations
Ashish Gupta, York Univ. (Canada)
Martin Villiger, York Univ. (United States)
Harvard Medical School (United States)
Nima Tabatabaei, York Univ. (Canada)

Published in SPIE Proceedings Vol. 10067:
Optical Elastography and Tissue Biomechanics IV
Kirill V. Larin; David D. Sampson, Editor(s)

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