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Proceedings Paper

Towards biological ion imaging in vivo: potassium selective photoacoustic nanosensor
Author(s): Chang Heon Lee; Jeffrey A. Folz; Wuliang Zhang; Janggun Jo; Xueding Wang; Raoul Kopelman
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Paper Abstract

Ion selective optical nanosensors allow accurate ion measurements in biological systems, without the physical limitations and invasiveness of ion selective electrodes. Optically based nanosensors (Photonic Explorers for Bioanalysis with Biologically Localized Embedding, PEBBLEs), have been optimized for fluorescence microscopy imaging, and have been applied for imaging various biochemical analytes. In here, we report the first example of a potassium selective nanosensor optimized for photoacoustic (PA) imaging. Notably, PA imaging overcomes the severe light penetration depth problem faced by fluorescence imaging in vivo. The new potassium selective nanosensor shows excellent response in the biological range, from 0 to 200 mM, as confirmed by both UV-Vis Spectroscopy and PA Spectroscopy. Furthermore, the K+ PEBBLE showed a 2 orders of magnitude, or higher, selectivity to K+ , relative to any other biological cations, such as Li+, Na+, Ca2+, and Mg2+.

Paper Details

Date Published: 22 February 2017
PDF: 7 pages
Proc. SPIE 10077, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV, 1007705 (22 February 2017); doi: 10.1117/12.2252708
Show Author Affiliations
Chang Heon Lee, Univ. of Michigan (United States)
Jeffrey A. Folz, Univ. of Michigan (United States)
Wuliang Zhang, Univ. of Michigan (United States)
Janggun Jo, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 10077:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV
Alexander N. Cartwright; Dan V. Nicolau; Dror Fixler, Editor(s)

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