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Proceedings Paper

In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion
Author(s): Julia M. Pakela; Seung Yup Lee; Taylor L. Hedrick; Karthik Vishwanath; Michael C. Helton; Yooree G. Chung; Noah J. Kolodziejski; Christopher J. Staples; Daniel R. McAdams; Daniel E. Fernandez; James F. Christian; Jameson O'Reilly; Dana Farkas; Brent B. Ward; Stephen E. Feinberg; Mary-Ann Mycek
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Paper Abstract

In reconstructive surgery, impeded blood flow in microvascular free flaps due to a compromise in arterial or venous patency secondary to blood clots or vessel spasms can rapidly result in flap failures. Thus, the ability to detect changes in microvascular free flaps is critical. In this paper, we report progress on in vivo pre-clinical testing of a compact, multimodal, fiber-based diffuse correlation and reflectance spectroscopy system designed to quantitatively monitor tissue perfusion in a porcine model’s surgically-grafted free flap. We also describe the device’s sensitivity to incremental blood flow changes and discuss the prospects for continuous perfusion monitoring in future clinical translational studies.

Paper Details

Date Published: 17 February 2017
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Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 100720U (17 February 2017); doi: 10.1117/12.2252620
Show Author Affiliations
Julia M. Pakela, Univ. of Michigan (United States)
Seung Yup Lee, Univ. of Michigan (United States)
Taylor L. Hedrick, Univ. of Michigan (United States)
Karthik Vishwanath, Miami Univ. (United States)
Michael C. Helton, Univ. of Michigan (United States)
Yooree G. Chung, Univ. of Michigan (United States)
Noah J. Kolodziejski, Radiation Monitoring Devices, Inc. (United States)
Christopher J. Staples, Radiation Monitoring Devices, Inc. (United States)
Daniel R. McAdams, Radiation Monitoring Devices, Inc. (United States)
Daniel E. Fernandez, Radiation Monitoring Devices, Inc. (United States)
James F. Christian, Radiation Monitoring Devices, Inc. (United States)
Jameson O'Reilly, Radiation Monitoring Devices, Inc. (United States)
Northeastern Univ. (United States)
Dana Farkas, Radiation Monitoring Devices, Inc. (United States)
Northeastern Univ. (United States)
Brent B. Ward, Univ. of Michigan (United States)
Stephen E. Feinberg, Univ. of Michigan (United States)
Mary-Ann Mycek, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 10072:
Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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