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Proceedings Paper

Concurrent OCT imaging of stimulus evoked retinal neural activation and hemodynamic responses
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Paper Abstract

It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes. The OCT images were acquired continuously during the pre-stimulation, light-stimulation, and post-stimulation phases. Stimulus-evoked intrinsic optical signals (IOSs) and hemodynamic changes were observed over time in blood-free and blood regions, respectively. Rapid IOSs change occurred almost immediately after stimulation. Both positive and negative signals were observed in adjacent retinal areas. The hemodynamic changes showed time delays after stimulation. The signal magnitudes induced by light stimulation were observed in blood regions and did not show significant changes in blood-free regions. These differences may arise from different mechanisms in blood vessels and neural tissues in response to light stimulation. These characteristics agreed well with our previous observations in mouse retinas. Further development of the multimodal OCT may provide a new imaging method for studying how retinal structures and metabolic and neural functions are affected by age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), and other diseases, which promises novel noninvasive biomarkers for early disease detection and reliable treatment evaluations of eye diseases.

Paper Details

Date Published: 8 February 2017
PDF: 7 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004522 (8 February 2017); doi: 10.1117/12.2252480
Show Author Affiliations
Taeyoon Son, Univ. of Illinois at Chicago (United States)
Benquan Wang, Univ. of Illinois at Chicago (United States)
Yiming Lu, Univ. of Illinois at Chicago (United States)
Yanjun Chen, Univ. of Illinois at Chicago (United States)
Dingcai Cao, Univ. of Illinois at Chicago (United States)
Xincheng Yao, Univ. of Illinois at Chicago (United States)

Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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