Share Email Print

Proceedings Paper

Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
Author(s): R. A. Byers; R. Maiti; S. G. Danby; E. J. Pang; B. Mitchell; M. J. Carré; R. Lewis; M. J. Cork; S. J. Matcher
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated dermal-epidermal junction in AD patients. Instead, angiographic extensions to OCT may allow for direct measurement of vascular depth, potentially presenting a more robust method of estimating the degree of epidermal thickening. Methods and results: To investigate microcirculatory changes within AD patients, volumes of angiographic OCT data were collected from 5 healthy volunteers and compared to that of 5 AD patients. Test sites included the cubital and popliteal fossa, which are commonly affected by AD. Measurements of the capillary loop and superficial arteriolar plexus (SAP) depth were acquired and used to estimate the lower and upper bounds of the undulating basement membrane of the dermal-epidermal junction. Furthermore, quantitative parameters such as vessel density and diameter were derived from each dataset and compared between groups. Capillary loop depth increased slightly for AD patients at the poplitial fossa and SAP was found to be measurably deeper in AD patients at both sites, likely due to localized epidermal hyperplasia.

Paper Details

Date Published: 6 February 2017
PDF: 9 pages
Proc. SPIE 10037, Photonics in Dermatology and Plastic Surgery, 100370V (6 February 2017); doi: 10.1117/12.2252407
Show Author Affiliations
R. A. Byers, The Univ. of Sheffield (United Kingdom)
R. Maiti, The Univ. of Sheffield (United Kingdom)
S. G. Danby, The Univ. of Sheffield (United Kingdom)
E. J. Pang, The Univ. of Sheffield (United Kingdom)
B. Mitchell, The Univ. of Sheffield (United Kingdom)
M. J. Carré, The Univ. of Sheffield (United Kingdom)
R. Lewis, The Univ. of Sheffield (United Kingdom)
M. J. Cork, The Univ. of Sheffield (United Kingdom)
S. J. Matcher, The Univ. of Sheffield (United Kingdom)

Published in SPIE Proceedings Vol. 10037:
Photonics in Dermatology and Plastic Surgery
Bernard Choi; Haishan Zeng; Nikiforos Kollias, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?