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Proceedings Paper

Towards in vivo breast skin characterization using multiphoton microscopy
Author(s): Ana Batista; Aisada Uchugonova; Hans Georg Breunig; Karsten König
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Paper Abstract

Breast cancer, the most common type of cancer in women worldwide, as well as its treatment (e.g. radiation therapy) can affect the human skin. Multiphoton imaging could provide new insights into these skin alterations non-invasively and with high-resolution. As a preparation for a later investigation involving patients, areas of the breast and forearm skin of healthy volunteers were imaged using the clinically certified multiphoton imaging tomograph MPTflex based on endogenous skin autofluorescence and second-harmonic signals. Depth-resolved image stacks were acquired in consecutive weeks to explore the influence of hormonal variations on the skin properties. Both breasts were considered and up to three different areas were imaged per session. Acquisition parameters were optimized to minimize artifacts caused by breathing-motion. As a first result, skin properties, such as the epidermal thickness, appear to be influenced by hormonal variations.

Paper Details

Date Published: 21 February 2017
PDF: 6 pages
Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100691Y (21 February 2017); doi: 10.1117/12.2252387
Show Author Affiliations
Ana Batista, Univ. des Saarlandes (Germany)
JenLab GmbH (Germany)
Aisada Uchugonova, Univ. des Saarlandes (Germany)
JenLab GmbH (Germany)
Hans Georg Breunig, JenLab GmbH (Germany)
Karsten König, Univ. des Saarlandes (Germany)
JenLab GmbH (Germany)

Published in SPIE Proceedings Vol. 10069:
Multiphoton Microscopy in the Biomedical Sciences XVII
Ammasi Periasamy; Peter T. C. So; Karsten König; Xiaoliang S. Xie, Editor(s)

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