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Proceedings Paper

Detection of small molecules with surface plasmon resonance by synergistic plasmonic effects of nanostructured surfaces and graphene
Author(s): Christa Genslein; Peter Hausler; Eva-Maria Kirchner; Rudolf Bierl; Antje J. Baeumner; Thomas Hirsch
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Paper Abstract

Surface plasmon resonance depends on the dielectric medium at the vicinity and makes it a quasi-universal detector. Therefore, and due to the label-free nature, SPR is a widely used sensing tool for real‐time monitoring molecular interactions of various analytes. However, detection of highly diluted analytes and small molecules (< 400 Da) is still challenging. Gold nanohole arrays provide plasmonic hotspots with improved surface sensitivity and 2D carbon nanomaterials enable binding near the surface. Both effects together are promising in the development of SPR sensors for the efficient determination of small molecules. Graphene is known for efficient binding of molecules with delocalized aromatic π-systems. Additionally, the electromagnetic field is locally enhanced and modulated by the interaction of graphene photonics with the plasmonics of metal nanostructures. The advantages of chemical vapor deposition (CVD) graphene over reduced graphene oxide (rGO) is illustrated by a proof of concept study. In comparison to substrates consisting of a continuous film the surface sensitivity is enhanced for a nanohole arrays and further improved for CVD graphene functionalization in contrast to rGO. The feasibility of the sensor was demonstrated for the detection of adenine down to a concentration of 0.9 μM.

Paper Details

Date Published: 17 February 2017
PDF: 7 pages
Proc. SPIE 10080, Plasmonics in Biology and Medicine XIV, 100800F (17 February 2017); doi: 10.1117/12.2252256
Show Author Affiliations
Christa Genslein, Univ. Regensburg (Germany)
Peter Hausler, OTH Regensburg (Germany)
Eva-Maria Kirchner, Univ. Regensburg (Germany)
Rudolf Bierl, OTH Regensburg (Germany)
Antje J. Baeumner, Univ. Regensburg (Germany)
Thomas Hirsch, Univ. Regensburg (Germany)

Published in SPIE Proceedings Vol. 10080:
Plasmonics in Biology and Medicine XIV
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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