Share Email Print

Proceedings Paper

Investigation of the efficacy of ultrafast laser in large bowel excision
Author(s): Syam Mohan P. C. Mohanan; Rainer J. Beck; Wojciech S. Góra; Sarah L. Perry; Mike Shires; David Jayne M.D.; Duncan P. Hand; Jonathan D. Shephard
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Local resection of early stage tumors in the large bowel via colonoscopy has been a widely accepted surgical modality for colon neoplasm treatment. The conventional electrocautery techniques used for the resection of neoplasia in the mucosal or submucosal layer of colon tissue has been shown to create obvious thermal necrosis to adjacent healthy tissues and lacks accuracy in resection. Ultrafast picosecond (ps) laser ablation using a wavelength of 1030 or 515 nm is a promising surgical tool to overcome the limitations seen with conventional surgical techniques. The purpose of this initial study is to analyze the depth of ablation or the extent of coagulation deployed by the laser as a function of pulse energy and fluence in an ex-vivo porcine model. Precise control of the depth of tissue removal is of paramount importance for bowel surgery where bowel perforation can lead to morbidity or mortality. Thus we investigate the regimes that are optimal for tissue resection and coagulation through plasma mediated ablation of healthy colon tissue. The ablated tissue samples were analyzed by standard histologic methods and a three dimensional optical profilometer technique. We demonstrate that ultrafast laser resection of colonic tissue can minimize the region of collateral thermal damage (<50 μm) with a controlled ablation depth. This surgical modality allows potentially easier removal of early stage lesions and has the capability to provide more control to the surgeon in comparison with a mechanical or electrocautery device.

Paper Details

Date Published: 15 February 2017
PDF: 5 pages
Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII, 1006207 (15 February 2017); doi: 10.1117/12.2251956
Show Author Affiliations
Syam Mohan P. C. Mohanan, Heriot-Watt Univ. (United Kingdom)
Rainer J. Beck, Heriot-Watt Univ. (United Kingdom)
Wojciech S. Góra, Heriot-Watt Univ. (United Kingdom)
Sarah L. Perry, Univ. of Leeds (United Kingdom)
Mike Shires, Univ. of Leeds (United Kingdom)
David Jayne M.D., Univ. of Leeds (United Kingdom)
Duncan P. Hand, Heriot-Watt Univ. (United Kingdom)
Jonathan D. Shephard, Heriot-Watt Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 10062:
Optical Interactions with Tissue and Cells XXVIII
E. Duco Jansen; Hope Thomas Beier, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?