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Proceedings Paper

Methods for non-surgical cancer nano-theranostics of ocular tumors in the mouse eye (Conference Presentation)
Author(s): Mayank Goswami; Xinlei Wang; Pengfei Zhang; Wenwu Xiao; Kit S. Lam; Edward N. Pugh Jr.; Robert J. Zawadzki

Paper Abstract

We will present our results of evaluating the feasibility of using the mouse eye as a window for non-invasive, long-term, optical investigation of xenograft models, using multimodal, cellular-resolution ocular imaging. As an “approachable part of the brain”, the retina allows examination of such issues as drug delivery across the blood retinal barrier (BRB) and blood brain barrier (BBB). Our custom-built wide-field SLO/OCT provided repeatable in vivo imaging over many weeks, allowing quantitative tracking of tumor growth, the delivery of theranostic nanoparticles, and the measurement of tumor microenvironment responses. Additionally, we were able to specifically control the spatial extent of light activated photodynamic therapy (PDT) and photothermal therapy (PTT) via efficient free radical and heat generation at the tumor site, respectively.

Paper Details

Date Published: 16 May 2017
PDF: 1 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100450C (16 May 2017); doi: 10.1117/12.2251803
Show Author Affiliations
Mayank Goswami, Univ. of California, Davis (United States)
Xinlei Wang, Univ. of California, Davis (United States)
Pengfei Zhang, Univ. of California, Davis (United States)
Wenwu Xiao, Univ. of California, Davis (United States)
Kit S. Lam, Univ. of California, Davis (United States)
Edward N. Pugh Jr., Univ. of California, Davis (United States)
Robert J. Zawadzki, Univ. of California, Davis (United States)

Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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