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Proceedings Paper

Using speckle to measure tissue dispersion in optical coherence tomography
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Paper Abstract

In Optical Coherence tomography (OCT), dispersion mismatches cause degradation of the image resolution. However, dispersion is specific to the material that is causing the effect and can therefore carry useful information regarding the composition of the samples. In this summary, we propose a novel technique for estimating the dispersion in tissue which uses the image speckle to calculate the PSF degradation and is therefore applicable to any tissue and can be implemented in vivo and in situ. A Wiener-type deconvolution algorithm was used to estimate the image PSF degradation from the speckle. The proposed method was verified ex vivo resulting in comparable values of the Group Velocity Dispersion (GVD) as obtained by a standard estimation technique described in the literature. The applicability to cancer diagnosis was evaluated on a small set of gastrointestinal normal and cancer OCT images. Using the statistics of the GVD estimate, the tissue classification resulted in 93% sensitivity and 73% specificity (84% correct classification rate). The success of these preliminary results indicates the potential of the proposed method which should be further investigated to elucidate its advantages and limitations.

Paper Details

Date Published: 17 February 2017
PDF: 4 pages
Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005329 (17 February 2017); doi: 10.1117/12.2251698
Show Author Affiliations
Christos Photiou, Univ. of Cyprus (Cyprus)
Evgenia Bousi, Univ. of Cyprus (Cyprus)
Ioanna Zouvani, Univ. of Cyprus (Cyprus)
Costas Pitris, Univ. of Cyprus (Cyprus)

Published in SPIE Proceedings Vol. 10053:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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