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Proceedings Paper

Observation of chest tumor using diffuse optical spectroscopy: time-varying Indocyanine green concentration in rabbit model
Author(s): Yikeun Kim; Sehun Kim; Sungwon Kim; Haeyoung Lee; Chulho Oak; Yeh-Chan Ahn
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Paper Abstract

This experiment was conducted by using the diffuse optical spectroscopy based on near-infrared light. The near-infrared light in the water window was used to see the change of molecular concentration in the living tissue. The experiment subject was New Zealand rabbits weighing 3 ± 0.3 kg. VX2 tumor cells were injected into the inside of the chest wall of rabbits. The concentration of indocyanine green (ICG) has been observed once every three days, after the size of the pleural tumor grew up over 1cm. We used five different wavelengths (732, 758, 805, 840, and 880 nm) with known ICG spectrum. The distance between light source and detector probes was fixed by 1 cm. The probes were placed on the skin right above the tumor with an aid of laparoscope. ICG was injected into rabbits via ear vein. The diffused light was measured through the tumor with time course using a spectrometer. These measured data enabled us to observe the change of ICG concentration in real time with respect to the baseline without ICG. ICG was present longer in tumor compared to normal tissue. This phenomenon is thought to be due to the excessive angiogenesis in the tumor tissue. Since this method can be applied to other cases easily, it is thought that there is a possibility of cancer screening with less cost and simple equipment.

Paper Details

Date Published: 17 February 2017
PDF: 4 pages
Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 1005923 (17 February 2017); doi: 10.1117/12.2251665
Show Author Affiliations
Yikeun Kim, Pukyong National Univ. (Korea, Republic of)
Sehun Kim, Pukyong National Univ. (Korea, Republic of)
Sungwon Kim, Kosin Univ. College of Medicine (Korea, Republic of)
Haeyoung Lee, Kosin Univ. College of Medicine (Korea, Republic of)
Chulho Oak, Kosin Univ. College of Medicine (Korea, Republic of)
Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 10059:
Optical Tomography and Spectroscopy of Tissue XII
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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