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Proceedings Paper

Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level
Author(s): Jie Hui; Yingchun Cao; Yi Zhang; Ayeeshik Kole; Pu Wang; Guangli Yu; Gregory Eakins; Michael Sturek; Weibiao Chen; Ji-Xin Cheng
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Paper Abstract

Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipidladen plaques by providing simultaneous morphological and lipid-specific chemical information of an artery wall. The clinical utility of IVPA-US technology requires real-time imaging and display at speed of video-rate level. Here, we demonstrate a compact and portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter, differentiated A-line strategy, and real-time image processing and display algorithms. By imaging pulsatile motion at different imaging speeds, 16 frames per second was deemed to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. Our lateral resolution results further verified the number of A-lines used for a cross-sectional IVPA image reconstruction. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology.

Paper Details

Date Published: 3 March 2017
PDF: 7 pages
Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640T (3 March 2017); doi: 10.1117/12.2251511
Show Author Affiliations
Jie Hui, Purdue Univ. (United States)
Yingchun Cao, Purdue Univ. (United States)
Yi Zhang, Purdue Univ. (United States)
Ayeeshik Kole, Purdue Univ. (United States)
Indiana Univ. (United States)
Pu Wang, Purdue Univ. (United States)
Guangli Yu, Nanjing Institute of Advanced Laser Technology (China)
Gregory Eakins, Purdue Univ. (United States)
Michael Sturek, Purdue Univ. (United States)
Indiana Univ. (United States)
Weibiao Chen, Nanjing Institute of Advanced Laser Technology (China)
Shanghai Institute of Optics and Fine Mechanics (China)
Ji-Xin Cheng, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 10064:
Photons Plus Ultrasound: Imaging and Sensing 2017
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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