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Proceedings Paper

Common-path biodynamic imaging for dynamic fluctuation spectroscopy of 3D living tissue
Author(s): Zhe Li; John Turek; David D. Nolte
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Paper Abstract

Biodynamic imaging is a novel 3D optical imaging technology based on short-coherence digital holography that measures intracellular motions of cells inside their natural microenvironments. Here both common-path and Mach-Zehnder designs are presented. Biological tissues such as tumor spheroids and ex vivo biopsies are used as targets, and backscattered light is collected as signal. Drugs are applied to samples, and their effects are evaluated by identifying biomarkers that capture intracellular dynamics from the reconstructed holograms. Through digital holography and coherence gating, information from different depths of the samples can be extracted, enabling the deep-tissue measurement of the responses to drugs.

Paper Details

Date Published: 3 March 2017
PDF: 6 pages
Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100631G (3 March 2017); doi: 10.1117/12.2251439
Show Author Affiliations
Zhe Li, Purdue Univ. (United States)
John Turek, Purdue Univ. (United States)
David D. Nolte, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 10063:
Dynamics and Fluctuations in Biomedical Photonics XIV
Valery V. Tuchin; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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