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Proceedings Paper

Impact of anatomical parameters on optical coherence tomography retinal nerve fiber layer thickness abnormality patterns
Author(s): Neda Baniasadi; Mengyu Wang; Hui Wang; Qingying Jin; Mufeed Mahd; Tobias Elze
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Paper Abstract

Purpose: To evaluate the effects of four anatomical parameters (angle between superior and inferior temporal retinal arteries [inter-artery angle, IAA], optic disc [OD] rotation, retinal curvature, and central retinal vessel trunk entry point location [CRVTL]) on retinal nerve fiber layer thickness (RNFLT) abnormality marks by OCT machines. Methods: Cirrus OCT circumpapillary RNFLT measurements and Humphrey visual fields (HVF 24-2) of 421 patients from a large glaucoma clinic were included. Ellipses were fitted to the OD borders. Ellipse rotation relative to the vertical axis defined OD rotation. CRVTL was manually marked on the horizontal axis of the ellipse on the OCT fundus image. IAA was calculated between manually marked retinal artery locations at the 1.73mm radius around OD. Retinal curvature was determined by the inner limiting membrane on the horizontal B-scan closest to the OD center. For each location on the circumpapillary scanning area, logistic regression was used to determine if each of the four parameters had a significant impact on RNFLT abnormality marks independent of disease severity. The results are presented on spatial maps of the entire scanning area. Results: Variations in IAA significantly influenced abnormality marks on 38.8% of the total scanning area, followed by CRVTL (19.2%) and retinal curvature (18.7%). The effect of OD rotation was negligible (<1%). Conclusions: A natural variation in IAA, retinal curvature, and CRVTL can affect OCT abnormality ratings, which may bias clinical diagnosis. Our spatial maps may help OCT manufacturers to introduce location specific norms to ensure that abnormality marks indicate ocular disease instead of variations in eye anatomy.

Paper Details

Date Published: 8 February 2017
PDF: 6 pages
Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100450P (8 February 2017); doi: 10.1117/12.2251435
Show Author Affiliations
Neda Baniasadi, Harvard Medical School (United States)
Univ. of Massachusetts Lowell (United States)
Mengyu Wang, Harvard Medical School (United States)
Hui Wang, Harvard Medical School (United States)
Jilin Univ. of Finance and Economics (China)
Qingying Jin, Harvard Medical School (United States)
Jilin Univ. (China)
Mufeed Mahd, Univ. of Massachusetts Lowell (United States)
Tobias Elze, Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 10045:
Ophthalmic Technologies XXVII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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